NCOA2-SGSM3 Fusion FISH Probe
The NCOA2-SGSM3 Fusion FISH Probe is used to confirm a fusion of the NCOA2 and SGSM3 genes. The fusion of the NCOA2 and SGSM3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCOA2-SGSM3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-RERE | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-REOR | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-REGO | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-REGR | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-REAQ | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-ORRE | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-OROR | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-ORGO | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-GORE | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-GOOR | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-GOGO | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-GOGR | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-GRRE | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-GROR | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-GRGO | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-GRGR | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-AQRE | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-AQOR | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-AQGO | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-AQGR | 20 (40 μL) | 200 μL |
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| NCOA2-SGSM3-20-AQAQ | 20 (40 μL) | 200 μL |
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NCOA2 Gene Summary
The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Gene Name: Nuclear Receptor Coactivator 2
Chromosome: CHR8: 71024266 -71316020
Locus: 8q13.3
SGSM3 Gene Summary
The Small G Protein Signaling Modulator 3 (SGSM3) gene is located on chr22 :40766594-40806293 at 22q13.1.
Gene Name: Small G Protein Signaling Modulator 3
Chromosome: CHR22: 40766594 -40806293
Locus: 22q13.1
Gene Diseases
The NCOA2 SGSM3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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