NCOA1-LPIN1 Fusion FISH Probe
The NCOA1-LPIN1 Fusion FISH Probe is used to confirm a fusion of the NCOA1 and LPIN1 genes. The fusion of the NCOA1 and LPIN1 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCOA1-LPIN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-RERE | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-REOR | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-REGO | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-REGR | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-REAQ | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-ORRE | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-OROR | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-ORGO | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-GORE | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-GOOR | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-GOGO | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-GOGR | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-GRRE | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-GROR | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-GRGO | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-GRGR | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-AQRE | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-AQOR | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-AQGO | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-AQGR | 20 (40 μL) | 200 μL |
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| NCOA1-LPIN1-20-AQAQ | 20 (40 μL) | 200 μL |
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NCOA1 Gene Summary
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Receptor Coactivator 1
Chromosome: CHR2: 24807345 -24993570
Locus: 2p23.3
LPIN1 Gene Summary
This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017]
Gene Name: Lipin 1
Chromosome: CHR2: 11886739 -11967533
Locus: 2p25.1
Gene Diseases
The NCOA1 LPIN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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