NCF2-PAPPA2 Fusion FISH Probe
The NCF2-PAPPA2 Fusion FISH Probe is used to confirm a fusion of the NCF2 and PAPPA2 genes. The fusion of the NCF2 and PAPPA2 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCF2-PAPPA2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-RERE | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-REOR | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-REGO | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-REGR | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-REAQ | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-ORRE | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-OROR | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-ORGO | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-GORE | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-GOOR | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-GOGO | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-GOGR | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-GRRE | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-GROR | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-GRGO | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-GRGR | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-AQRE | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-AQOR | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-AQGO | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-AQGR | 20 (40 μL) | 200 μL |
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| NCF2-PAPPA2-20-AQAQ | 20 (40 μL) | 200 μL |
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NCF2 Gene Summary
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]
Gene Name: Neutrophil Cytosolic Factor 2
Chromosome: CHR1: 183524696 -183560056
Locus: 1q25.3
PAPPA2 Gene Summary
This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Gene Name: Pappalysin 2
Chromosome: CHR1: 176432306 -176811970
Locus: 1q25.2
Gene Diseases
The NCF2 PAPPA2 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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