NCALD-UBR5 Fusion FISH Probe
The NCALD-UBR5 Fusion FISH Probe is used to confirm a fusion of the NCALD and UBR5 genes. The fusion of the NCALD and UBR5 genes has been associated with Uterine Corpus Endometrial Carcinoma, Uterine Corpus Endometrial Carcinoma, and Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCALD-UBR5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-RERE | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-REOR | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-REGO | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-REGR | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-REAQ | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-ORRE | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-OROR | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-ORGO | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-GORE | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-GOOR | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-GOGO | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-GOGR | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-GRRE | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-GROR | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-GRGO | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-GRGR | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-AQRE | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-AQOR | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-AQGO | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-AQGR | 20 (40 μL) | 200 μL |
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| NCALD-UBR5-20-AQAQ | 20 (40 μL) | 200 μL |
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UBR5 Gene Summary
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]
Gene Name: Ubiquitin Protein Ligase E3 Component N-recognin 5
Chromosome: CHR8: 103264501 -103424917
Locus: 8q22.3
NCALD Gene Summary
This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Neurocalcin Delta
Chromosome: CHR8: 102698769 -103137135
Locus: 8q22.3
Gene Diseases
The NCALD UBR5 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Uterine Corpus Endometrial Carcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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