NCALD-NSMCE2 Fusion FISH Probe
The NCALD-NSMCE2 Fusion FISH Probe is used to confirm a fusion of the NCALD and NSMCE2 genes. The fusion of the NCALD and NSMCE2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCALD-NSMCE2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-RERE | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-REOR | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-REGO | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-REGR | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-REAQ | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-ORRE | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-OROR | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-ORGO | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-GORE | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-GOOR | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-GOGO | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-GOGR | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-GRRE | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-GROR | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-GRGO | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-GRGR | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-AQRE | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-AQOR | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-AQGO | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-AQGR | 20 (40 μL) | 200 μL |
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| NCALD-NSMCE2-20-AQAQ | 20 (40 μL) | 200 μL |
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NCALD Gene Summary
This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Neurocalcin Delta
Chromosome: CHR8: 102698769 -103137135
Locus: 8q22.3
NSMCE2 Gene Summary
This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017]
Gene Name: NSE2/MMS21 Homolog, SMC5-SMC6 Complex SUMO Ligase
Chromosome: CHR8: 126104082 -126379367
Locus: 8q24.13
Gene Diseases
The NCALD NSMCE2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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