NBPF3-EPHB2 Fusion FISH Probe
The NBPF3-EPHB2 Fusion FISH Probe is used to confirm a fusion of the NBPF3 and EPHB2 genes. The fusion of the NBPF3 and EPHB2 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NBPF3-EPHB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-RERE | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-REOR | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-REGO | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-REGR | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-REAQ | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-ORRE | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-OROR | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-ORGO | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-GORE | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-GOOR | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-GOGO | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-GOGR | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-GRRE | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-GROR | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-GRGO | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-GRGR | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-AQRE | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-AQOR | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-AQGO | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-AQGR | 20 (40 μL) | 200 μL |
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| NBPF3-EPHB2-20-AQAQ | 20 (40 μL) | 200 μL |
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EPHB2 Gene Summary
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]
Gene Name: EPH Receptor B2
Chromosome: CHR1: 23037330 -23241823
Locus: 1p36.12
NBPF3 Gene Summary
This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. DUF1220 copy number variations in human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, cognitive disability, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. [provided by RefSeq, Feb 2013]
Gene Name: NBPF Member 3
Chromosome: CHR1: 21766630 -21811393
Locus: 1p36.12
Gene Diseases
The NBPF3 EPHB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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