NBL1-STAT6 Fusion FISH Probe
The NBL1-STAT6 Fusion FISH Probe is used to confirm a fusion of the NBL1 and STAT6 genes. The fusion of the NBL1 and STAT6 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NBL1-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-RERE | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-REOR | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-REGO | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-REGR | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-OROR | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-GORE | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-GROR | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
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| NBL1-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
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NBL1 Gene Summary
This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]
Gene Name: Neuroblastoma 1, DAN Family BMP Antagonist
Chromosome: CHR1: 19969722 -19984949
Locus: 1p36.13
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The NBL1 STAT6 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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