NBEA-BRCA2 Fusion FISH Probe
The NBEA-BRCA2 Fusion FISH Probe is used to confirm a fusion of the NBEA and BRCA2 genes. The fusion of the NBEA and BRCA2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NBEA-BRCA2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-RERE | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-REOR | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-REGO | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-REGR | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-REAQ | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-ORRE | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-OROR | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-ORGO | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-ORAQ | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-GORE | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-GOOR | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-GOGO | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-GOGR | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-GOAQ | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-GRRE | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-GROR | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-GRGO | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-GRGR | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-GRAQ | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-AQRE | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-AQOR | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-AQGO | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-AQGR | 20 (40 μL) | 200 μL |
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| NBEA-BRCA2-20-AQAQ | 20 (40 μL) | 200 μL |
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BRCA2 Gene Summary
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
Gene Name: BRCA2, DNA Repair Associated
Chromosome: CHR13: 32889616 -32973809
Locus: 13q13.1
NBEA Gene Summary
This gene encodes a member of a large, diverse group of A-kinase anchor proteins that target the activity of protein kinase A to specific subcellular sites by binding to its type II regulatory subunits. Brain-specific expression and coat protein-like membrane recruitment of a highly similar protein in mouse suggest an involvement in neuronal post-Golgi membrane traffic. Mutations in this gene may be associated with a form of autism. This gene and its expression are frequently disrupted in patients with multiple myeloma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants may exist, but their full-length nature has not been determined.[provided by RefSeq, Feb 2011]
Gene Name: Neurobeachin
Chromosome: CHR13: 35516423 -36246873
Locus: 13q13.3
Gene Diseases
The NBEA BRCA2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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