NARS2-ME3 Fusion FISH Probe
The NARS2-ME3 Fusion FISH Probe is used to confirm a fusion of the NARS2 and ME3 genes. The fusion of the NARS2 and ME3 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NARS2-ME3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-RERE | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-REOR | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-REGO | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-REGR | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-OROR | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-GORE | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-GROR | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| NARS2-ME3-20-AQAQ | 20 (40 μL) | 200 μL |
|
ME3 Gene Summary
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Malic Enzyme 3
Chromosome: CHR11: 86152149 -86383678
Locus: 11q14.2
NARS2 Gene Summary
This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of asparagine to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 24 (COXPD24). [provided by RefSeq, Mar 2015]
Gene Name: Asparaginyl-tRNA Synthetase 2, Mitochondrial
Chromosome: CHR11: 78147006 -78285909
Locus: 11q14.1
Gene Diseases
The NARS2 ME3 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|