NARF-KRT24 Fusion FISH Probe
The NARF-KRT24 Fusion FISH Probe is used to confirm a fusion of the NARF and KRT24 genes. The fusion of the NARF and KRT24 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NARF-KRT24-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-RERE | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-REOR | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-REGO | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-REGR | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-REAQ | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-ORRE | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-OROR | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-ORGO | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-ORAQ | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-GORE | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-GOOR | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-GOGO | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-GOGR | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-GOAQ | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-GRRE | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-GROR | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-GRGO | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-GRGR | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-GRAQ | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-AQRE | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-AQOR | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-AQGO | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-AQGR | 20 (40 μL) | 200 μL |
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| NARF-KRT24-20-AQAQ | 20 (40 μL) | 200 μL |
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NARF Gene Summary
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Prelamin A Recognition Factor
Chromosome: CHR17: 80416059 -80446143
Locus: 17q25.3
KRT24 Gene Summary
This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jun 2009]
Gene Name: Keratin 24
Chromosome: CHR17: 38854242 -38860002
Locus: 17q21.2
Gene Diseases
The NARF KRT24 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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