NAGS-PYY Fusion FISH Probe
The NAGS-PYY Fusion FISH Probe is used to confirm a fusion of the NAGS and PYY genes. The fusion of the NAGS and PYY genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NAGS-PYY-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-RERE | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-REOR | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-REGO | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-REGR | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-REAQ | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-ORRE | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-OROR | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-ORGO | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-ORAQ | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-GORE | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-GOOR | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-GOGO | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-GOGR | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-GOAQ | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-GRRE | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-GROR | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-GRGO | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-GRGR | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-GRAQ | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-AQRE | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-AQOR | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-AQGO | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-AQGR | 20 (40 μL) | 200 μL |
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| NAGS-PYY-20-AQAQ | 20 (40 μL) | 200 μL |
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PYY Gene Summary
This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]
Gene Name: Peptide YY
Chromosome: CHR17: 42030106 -42081837
Locus: 17q21.31
NAGS Gene Summary
The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia. [provided by RefSeq, Jul 2008]
Gene Name: N-acetylglutamate Synthase
Chromosome: CHR17: 42082031 -42086436
Locus: 17q21.31
Gene Diseases
The NAGS PYY Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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