NAB2-STAT6 Fusion FISH Probe
The NAB2-STAT6 Fusion FISH Probe is used to confirm a fusion of the NAB2 and STAT6 genes. The fusion of the NAB2 and STAT6 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NAB2-STAT6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-RERE | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-REOR | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-REGO | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-REGR | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-OROR | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-GORE | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-GROR | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| NAB2-STAT6-20-AQAQ | 20 (40 μL) | 200 μL |
|
NAB2 Gene Summary
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: NGFI-A Binding Protein 2
Chromosome: CHR12: 57482676 -57489259
Locus: 12q13.3
STAT6 Gene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Name: Signal Transducer And Activator Of Transcription 6
Chromosome: CHR12: 57489186 -57505196
Locus: 12q13.3
Gene Diseases
The NAB2 STAT6 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|