NAA35-LAMC3 Fusion FISH Probe
The NAA35-LAMC3 Fusion FISH Probe is used to confirm a fusion of the NAA35 and LAMC3 genes. The fusion of the NAA35 and LAMC3 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NAA35-LAMC3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-RERE | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-REOR | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-REGO | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-REGR | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-REAQ | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-ORRE | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-OROR | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-ORGO | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-ORAQ | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-GORE | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-GOOR | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-GOGO | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-GOGR | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-GOAQ | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-GRRE | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-GROR | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-GRGO | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-GRGR | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-GRAQ | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-AQRE | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-AQOR | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-AQGO | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-AQGR | 20 (40 μL) | 200 μL |
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| NAA35-LAMC3-20-AQAQ | 20 (40 μL) | 200 μL |
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LAMC3 Gene Summary
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 3. The gamma 3 chain is most similar to the gamma 1 chain, and contains all the 6 domains expected of the gamma chain. It is a component of laminin 12. The gamma 3 chain is broadly expressed in skin, heart, lung, and the reproductive tracts. In skin, it is seen within the basement membrane of the dermal-epidermal junction at points of nerve penetration. Gamma 3 is also a prominent element of the apical surface of ciliated epithelial cells of lung, oviduct, epididymis, ductus deferens, and seminiferous tubules. The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. [provided by RefSeq, Aug 2011]
Gene Name: Laminin Subunit Gamma 3
Chromosome: CHR9: 133884503 -133968446
Locus: 9q34.12
NAA35 Gene Summary
The N(alpha)-acetyltransferase 35, NatC Auxiliary Subunit (NAA35) gene is located on chr9 :88556056-88637217 at 9q21.33.
Gene Name: N(alpha)-acetyltransferase 35, NatC Auxiliary Subunit
Chromosome: CHR9: 88556056 -88637217
Locus: 9q21.33
Gene Diseases
The NAA35 LAMC3 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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