MYT1L-POMC Fusion FISH Probe
The MYT1L-POMC Fusion FISH Probe is used to confirm a fusion of the MYT1L and POMC genes. The fusion of the MYT1L and POMC genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYT1L-POMC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-RERE | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-REOR | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-REGO | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-REGR | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-REAQ | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-ORRE | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-OROR | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-ORGO | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-GORE | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-GOOR | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-GOGO | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-GOGR | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-GRRE | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-GROR | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-GRGO | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-GRGR | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-AQRE | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-AQOR | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-AQGO | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-AQGR | 20 (40 μL) | 200 μL |
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| MYT1L-POMC-20-AQAQ | 20 (40 μL) | 200 μL |
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POMC Gene Summary
This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jan 2016]
Gene Name: Proopiomelanocortin
Chromosome: CHR2: 25383721 -25391559
Locus: 2p23.3
MYT1L Gene Summary
This gene encodes a member of the zinc finger superfamily of transcription factors whose expression, thus far, has been found only in neuronal tissues. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with an autosomal dominant form of cognitive disability and with autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Jul 2017]
Gene Name: Myelin Transcription Factor 1 Like
Chromosome: CHR2: 1792884 -2335045
Locus: 2p25.3
Gene Diseases
The MYT1L POMC Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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