MYRIP-MLH1 Fusion FISH Probe
The MYRIP-MLH1 Fusion FISH Probe is used to confirm a fusion of the MYRIP and MLH1 genes. The fusion of the MYRIP and MLH1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYRIP-MLH1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-RERE | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-REOR | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-REGO | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-REGR | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-REAQ | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-ORRE | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-OROR | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-ORGO | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-GORE | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-GOOR | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-GOGO | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-GOGR | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-GRRE | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-GROR | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-GRGO | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-GRGR | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-AQRE | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-AQOR | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-AQGO | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-AQGR | 20 (40 μL) | 200 μL |
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| MYRIP-MLH1-20-AQAQ | 20 (40 μL) | 200 μL |
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MLH1 Gene Summary
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
Gene Name: MutL Homolog 1
Chromosome: CHR3: 37034840 -37092337
Locus: 3p22.2
MYRIP Gene Summary
The Myosin VIIA And Rab Interacting Protein (MYRIP) gene is located on chr3 :39851302-40301811 at 3p22.1.
Gene Name: Myosin VIIA And Rab Interacting Protein
Chromosome: CHR3: 39851302 -40301811
Locus: 3p22.1
Gene Diseases
The MYRIP MLH1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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