MYO9B-DOCK6 Fusion FISH Probe
The MYO9B-DOCK6 Fusion FISH Probe is used to confirm a fusion of the MYO9B and DOCK6 genes. The fusion of the MYO9B and DOCK6 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYO9B-DOCK6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-RERE | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-REOR | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-REGO | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-REGR | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-REAQ | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-ORRE | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-OROR | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-ORGO | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-GORE | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-GOOR | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-GOGO | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-GOGR | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-GRRE | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-GROR | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-GRGO | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-GRGR | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-AQRE | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-AQOR | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-AQGO | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-AQGR | 20 (40 μL) | 200 μL |
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| MYO9B-DOCK6-20-AQAQ | 20 (40 μL) | 200 μL |
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MYO9B Gene Summary
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Myosin IXB
Chromosome: CHR19: 17186590 -17324104
Locus: 19p13.11
DOCK6 Gene Summary
This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]
Gene Name: Dedicator Of Cytokinesis 6
Chromosome: CHR19: 11309970 -11373157
Locus: 19p13.2
Gene Diseases
The MYO9B DOCK6 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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