MYO6-SENP6 Fusion FISH Probe
The MYO6-SENP6 Fusion FISH Probe is used to confirm a fusion of the MYO6 and SENP6 genes. The fusion of the MYO6 and SENP6 genes has been associated with Lung Adenocarcinoma, Lung Adenocarcinoma, Uterine Corpus Endometrial Carcinoma, Uterine Corpus Endometrial Carcinoma, Breast Invasive Carcinoma, Head And Neck Squamous Cell Carcinoma , and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MYO6-SENP6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-RERE | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-REOR | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-REGO | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-REGR | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-OROR | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-GORE | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-GROR | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| MYO6-SENP6-20-AQAQ | 20 (40 μL) | 200 μL |
|
MYO6 Gene Summary
This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Gene Name: Myosin VI
Chromosome: CHR6: 76458908 -76629254
Locus: 6q14.1
SENP6 Gene Summary
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
Gene Name: SUMO1/sentrin Specific Peptidase 6
Chromosome: CHR6: 76311621 -76427994
Locus: 6q14.1
Gene Diseases
The MYO6 SENP6 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Adenocarcinoma |
| Lung Adenocarcinoma |
| Uterine Corpus Endometrial Carcinoma |
| Uterine Corpus Endometrial Carcinoma |
| Breast Invasive Carcinoma |
| Head And Neck Squamous Cell Carcinoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|