MYO5B-MBD1 Fusion FISH Probe
The MYO5B-MBD1 Fusion FISH Probe is used to confirm a fusion of the MYO5B and MBD1 genes. The fusion of the MYO5B and MBD1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYO5B-MBD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-RERE | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-REOR | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-REGO | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-REGR | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-REAQ | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-ORRE | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-OROR | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-ORGO | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-GORE | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-GOOR | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-GOGO | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-GOGR | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-GRRE | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-GROR | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-GRGO | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-GRGR | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-AQRE | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-AQOR | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-AQGO | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-AQGR | 20 (40 μL) | 200 μL |
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| MYO5B-MBD1-20-AQAQ | 20 (40 μL) | 200 μL |
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MBD1 Gene Summary
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]
Gene Name: Methyl-CpG Binding Domain Protein 1
Chromosome: CHR18: 47793251 -47808144
Locus: 18q21.1
MYO5B Gene Summary
The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease. [provided by RefSeq, Sep 2009]
Gene Name: Myosin VB
Chromosome: CHR18: 47349155 -47721451
Locus: 18q21.1
Gene Diseases
The MYO5B MBD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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