MYO5B-DCC Fusion FISH Probe
The MYO5B-DCC Fusion FISH Probe is used to confirm a fusion of the MYO5B and DCC genes. The fusion of the MYO5B and DCC genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYO5B-DCC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-RERE | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-REOR | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-REGO | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-REGR | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-REAQ | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-ORRE | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-OROR | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-ORGO | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-GORE | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-GOOR | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-GOGO | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-GOGR | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-GRRE | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-GROR | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-GRGO | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-GRGR | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-AQRE | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-AQOR | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-AQGO | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-AQGR | 20 (40 μL) | 200 μL |
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| MYO5B-DCC-20-AQAQ | 20 (40 μL) | 200 μL |
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DCC Gene Summary
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
Gene Name: DCC Netrin 1 Receptor
Chromosome: CHR18: 49866541 -51062273
Locus: 18q21.2
MYO5B Gene Summary
The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease. [provided by RefSeq, Sep 2009]
Gene Name: Myosin VB
Chromosome: CHR18: 47349155 -47721451
Locus: 18q21.1
Gene Diseases
The MYO5B DCC Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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