MYO5A-OIP5 Fusion FISH Probe
The MYO5A-OIP5 Fusion FISH Probe is used to confirm a fusion of the MYO5A and OIP5 genes. The fusion of the MYO5A and OIP5 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYO5A-OIP5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-RERE | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-REOR | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-REGO | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-REGR | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-REAQ | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-ORRE | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-OROR | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-ORGO | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-GORE | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-GOOR | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-GOGO | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-GOGR | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-GRRE | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-GROR | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-GRGO | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-GRGR | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-AQRE | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-AQOR | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-AQGO | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-AQGR | 20 (40 μL) | 200 μL |
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| MYO5A-OIP5-20-AQAQ | 20 (40 μL) | 200 μL |
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MYO5A Gene Summary
This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. [provided by RefSeq, Dec 2008]
Gene Name: Myosin VA
Chromosome: CHR15: 52599479 -52821247
Locus: 15q21.2
OIP5 Gene Summary
The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Gene Name: Opa Interacting Protein 5
Chromosome: CHR15: 41601465 -41624819
Locus: 15q15.1
Gene Diseases
The MYO5A OIP5 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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