MYO1E-BNIP2 Fusion FISH Probe
The MYO1E-BNIP2 Fusion FISH Probe is used to confirm a fusion of the MYO1E and BNIP2 genes. The fusion of the MYO1E and BNIP2 genes has been associated with Lung Adenocarcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYO1E-BNIP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-RERE | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-REOR | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-REGO | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-REGR | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-REAQ | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-ORRE | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-OROR | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-ORGO | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-GORE | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-GOOR | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-GOGO | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-GOGR | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-GRRE | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-GROR | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-GRGO | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-GRGR | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-AQRE | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-AQOR | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-AQGO | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-AQGR | 20 (40 μL) | 200 μL |
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| MYO1E-BNIP2-20-AQAQ | 20 (40 μL) | 200 μL |
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BNIP2 Gene Summary
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Gene Name: BCL2 Interacting Protein 2
Chromosome: CHR15: 59955061 -59981642
Locus: 15q22.2
MYO1E Gene Summary
This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17. [provided by RefSeq, Jan 2012]
Gene Name: Myosin IE
Chromosome: CHR15: 59428562 -59665071
Locus: 15q22.2
Gene Diseases
The MYO1E BNIP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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