MYO1C-SMG6 Fusion FISH Probe
The MYO1C-SMG6 Fusion FISH Probe is used to confirm a fusion of the MYO1C and SMG6 genes. The fusion of the MYO1C and SMG6 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYO1C-SMG6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-RERE | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-REOR | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-REGO | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-REGR | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-REAQ | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-ORRE | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-OROR | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-ORGO | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-GORE | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-GOOR | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-GOGO | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-GOGR | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-GRRE | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-GROR | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-GRGO | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-GRGR | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-AQRE | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-AQOR | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-AQGO | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-AQGR | 20 (40 μL) | 200 μL |
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| MYO1C-SMG6-20-AQAQ | 20 (40 μL) | 200 μL |
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MYO1C Gene Summary
This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]
Gene Name: Myosin IC
Chromosome: CHR17: 1367479 -1396001
Locus: 17p13.3
SMG6 Gene Summary
This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]
Gene Name: SMG6, Nonsense Mediated MRNA Decay Factor
Chromosome: CHR17: 1963132 -2207069
Locus: 17p13.3
Gene Diseases
The MYO1C SMG6 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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