MYO15A-TOP3A Fusion FISH Probe
The MYO15A-TOP3A Fusion FISH Probe is used to confirm a fusion of the MYO15A and TOP3A genes. The fusion of the MYO15A and TOP3A genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYO15A-TOP3A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-RERE | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-REOR | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-REGO | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-REGR | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-REAQ | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-ORRE | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-OROR | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-ORGO | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-GORE | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-GOOR | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-GOGO | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-GOGR | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-GRRE | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-GROR | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-GRGO | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-GRGR | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-AQRE | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-AQOR | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-AQGO | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-AQGR | 20 (40 μL) | 200 μL |
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| MYO15A-TOP3A-20-AQAQ | 20 (40 μL) | 200 μL |
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TOP3A Gene Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Gene Name: DNA Topoisomerase III Alpha
Chromosome: CHR17: 18177234 -18218321
Locus: 17p11.2
MYO15A Gene Summary
This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
Gene Name: Myosin XVA
Chromosome: CHR17: 18012019 -18083116
Locus: 17p11.2
Gene Diseases
The MYO15A TOP3A Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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