MYLK-VAMP4 Fusion FISH Probe
The MYLK-VAMP4 Fusion FISH Probe is used to confirm a fusion of the MYLK and VAMP4 genes. The fusion of the MYLK and VAMP4 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYLK-VAMP4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-RERE | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-REOR | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-REGO | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-REGR | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-REAQ | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-ORRE | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-OROR | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-ORGO | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-GORE | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-GOOR | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-GOGO | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-GOGR | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-GRRE | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-GROR | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-GRGO | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-GRGR | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-AQRE | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-AQOR | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-AQGO | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-AQGR | 20 (40 μL) | 200 μL |
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| MYLK-VAMP4-20-AQAQ | 20 (40 μL) | 200 μL |
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MYLK Gene Summary
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
Gene Name: Myosin Light Chain Kinase
Chromosome: CHR3: 123331142 -123603149
Locus: 3q21.1
VAMP4 Gene Summary
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008]
Gene Name: Vesicle Associated Membrane Protein 4
Chromosome: CHR1: 171669295 -171711379
Locus: 1q24.3
Gene Diseases
The MYLK VAMP4 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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