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MYLK-PLXND1 Fusion FISH Probe

The MYLK-PLXND1 Fusion FISH Probe is used to confirm a fusion of the MYLK and PLXND1 genes. The fusion of the MYLK and PLXND1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
MYLK-PLXND1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MYLK-PLXND1-20-RERE 20 (40 μL) 200 μL
MYLK-PLXND1-20-REOR 20 (40 μL) 200 μL
MYLK-PLXND1-20-REGO 20 (40 μL) 200 μL
MYLK-PLXND1-20-REGR 20 (40 μL) 200 μL
MYLK-PLXND1-20-REAQ 20 (40 μL) 200 μL
MYLK-PLXND1-20-ORRE 20 (40 μL) 200 μL
MYLK-PLXND1-20-OROR 20 (40 μL) 200 μL
MYLK-PLXND1-20-ORGO 20 (40 μL) 200 μL
MYLK-PLXND1-20-ORAQ 20 (40 μL) 200 μL
MYLK-PLXND1-20-GORE 20 (40 μL) 200 μL
MYLK-PLXND1-20-GOOR 20 (40 μL) 200 μL
MYLK-PLXND1-20-GOGO 20 (40 μL) 200 μL
MYLK-PLXND1-20-GOGR 20 (40 μL) 200 μL
MYLK-PLXND1-20-GOAQ 20 (40 μL) 200 μL
MYLK-PLXND1-20-GRRE 20 (40 μL) 200 μL
MYLK-PLXND1-20-GROR 20 (40 μL) 200 μL
MYLK-PLXND1-20-GRGO 20 (40 μL) 200 μL
MYLK-PLXND1-20-GRGR 20 (40 μL) 200 μL
MYLK-PLXND1-20-GRAQ 20 (40 μL) 200 μL
MYLK-PLXND1-20-AQRE 20 (40 μL) 200 μL
MYLK-PLXND1-20-AQOR 20 (40 μL) 200 μL
MYLK-PLXND1-20-AQGO 20 (40 μL) 200 μL
MYLK-PLXND1-20-AQGR 20 (40 μL) 200 μL
MYLK-PLXND1-20-AQAQ 20 (40 μL) 200 μL

MYLK Gene Summary

This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]

Gene Name: Myosin Light Chain Kinase

Chromosome: CHR3: 123331142 -123603149

Locus: 3q21.1

PLXND1 Gene Summary

The Plexin D1 (PLXND1) gene is located on chr3 :129274055-129325582 at 3q22.1.

Gene Name: Plexin D1

Chromosome: CHR3: 129274055 -129325582

Locus: 3q22.1

Gene Diseases

The MYLK PLXND1 Fusion has been associated with the following diseases:

Disease Name
Liver Hepatocellular Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.