MYH9-PVALB Fusion FISH Probe
The MYH9-PVALB Fusion FISH Probe is used to confirm a fusion of the MYH9 and PVALB genes. The fusion of the MYH9 and PVALB genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYH9-PVALB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-RERE | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-REOR | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-REGO | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-REGR | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-REAQ | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-ORRE | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-OROR | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-ORGO | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-GORE | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-GOOR | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-GOGO | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-GOGR | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-GRRE | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-GROR | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-GRGO | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-GRGR | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-AQRE | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-AQOR | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-AQGO | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-AQGR | 20 (40 μL) | 200 μL |
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| MYH9-PVALB-20-AQAQ | 20 (40 μL) | 200 μL |
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MYH9 Gene Summary
This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]
Gene Name: Myosin Heavy Chain 9
Chromosome: CHR22: 36677322 -36784063
Locus: 22q12.3
PVALB Gene Summary
The protein encoded by this gene is a high affinity calcium ion-binding protein that is structurally and functionally similar to calmodulin and troponin C. The encoded protein is thought to be involved in muscle relaxation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Gene Name: Parvalbumin
Chromosome: CHR22: 37196744 -37215517
Locus: 22q12.3
Gene Diseases
The MYH9 PVALB Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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