MYH9-PLAT Fusion FISH Probe
The MYH9-PLAT Fusion FISH Probe is used to confirm a fusion of the MYH9 and PLAT genes. The fusion of the MYH9 and PLAT genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYH9-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-RERE | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-REOR | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-REGO | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-REGR | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-OROR | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-GORE | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-GROR | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| MYH9-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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MYH9 Gene Summary
This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]
Gene Name: Myosin Heavy Chain 9
Chromosome: CHR22: 36677322 -36784063
Locus: 22q12.3
PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
Gene Diseases
The MYH9 PLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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