MYH9-KLK3 Fusion FISH Probe
The MYH9-KLK3 Fusion FISH Probe is used to confirm a fusion of the MYH9 and KLK3 genes. The fusion of the MYH9 and KLK3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYH9-KLK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-RERE | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-REOR | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-REGO | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-REGR | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-REAQ | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-ORRE | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-OROR | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-ORGO | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-GORE | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-GOOR | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-GOGO | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-GOGR | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-GRRE | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-GROR | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-GRGO | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-GRGR | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-AQRE | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-AQOR | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-AQGO | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-AQGR | 20 (40 μL) | 200 μL |
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| MYH9-KLK3-20-AQAQ | 20 (40 μL) | 200 μL |
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KLK3 Gene Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Kallikrein Related Peptidase 3
Chromosome: CHR19: 51358170 -51364020
Locus: 19q13.33
MYH9 Gene Summary
This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]
Gene Name: Myosin Heavy Chain 9
Chromosome: CHR22: 36677322 -36784063
Locus: 22q12.3
Gene Diseases
The MYH9 KLK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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