MYH9-DNASE1 Fusion FISH Probe
The MYH9-DNASE1 Fusion FISH Probe is used to confirm a fusion of the MYH9 and DNASE1 genes. The fusion of the MYH9 and DNASE1 genes has been associated with Kidney Chromophobe. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYH9-DNASE1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-RERE | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-REOR | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-REGO | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-REGR | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-REAQ | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-ORRE | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-OROR | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-ORGO | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-GORE | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-GOOR | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-GOGO | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-GOGR | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-GRRE | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-GROR | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-GRGO | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-GRGR | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-AQRE | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-AQOR | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-AQGO | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-AQGR | 20 (40 μL) | 200 μL |
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| MYH9-DNASE1-20-AQAQ | 20 (40 μL) | 200 μL |
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DNASE1 Gene Summary
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Deoxyribonuclease 1
Chromosome: CHR16: 3702939 -3708096
Locus: 16p13.3
MYH9 Gene Summary
This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]
Gene Name: Myosin Heavy Chain 9
Chromosome: CHR22: 36677322 -36784063
Locus: 22q12.3
Gene Diseases
The MYH9 DNASE1 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Chromophobe |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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