MYH9-CACNA1C Fusion FISH Probe
The MYH9-CACNA1C Fusion FISH Probe is used to confirm a fusion of the MYH9 and CACNA1C genes. The fusion of the MYH9 and CACNA1C genes has been associated with Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MYH9-CACNA1C-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-RERE | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-REOR | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-REGO | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-REGR | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-OROR | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-GORE | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-GROR | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| MYH9-CACNA1C-20-AQAQ | 20 (40 μL) | 200 μL |
|
CACNA1C Gene Summary
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
Gene Name: Calcium Voltage-gated Channel Subunit Alpha1 C
Chromosome: CHR12: 2162415 -2807115
Locus: 12p13.33
MYH9 Gene Summary
This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]
Gene Name: Myosin Heavy Chain 9
Chromosome: CHR22: 36677322 -36784063
Locus: 22q12.3
Gene Diseases
The MYH9 CACNA1C Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Acute Myeloid Leukemia |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|