MYH11-TYK2 Fusion FISH Probe
The MYH11-TYK2 Fusion FISH Probe is used to confirm a fusion of the MYH11 and TYK2 genes. The fusion of the MYH11 and TYK2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYH11-TYK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-RERE | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-REOR | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-REGO | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-REGR | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-REAQ | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-ORRE | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-OROR | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-ORGO | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-GORE | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-GOOR | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-GOGO | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-GOGR | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-GRRE | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-GROR | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-GRGO | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-GRGR | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-AQRE | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-AQOR | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-AQGO | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-AQGR | 20 (40 μL) | 200 μL |
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| MYH11-TYK2-20-AQAQ | 20 (40 μL) | 200 μL |
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MYH11 Gene Summary
The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Myosin Heavy Chain 11
Chromosome: CHR16: 15796991 -15950887
Locus: 16p13.11
TYK2 Gene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase 2
Chromosome: CHR19: 10461203 -10491248
Locus: 19p13.2
Gene Diseases
The MYH11 TYK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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