MYH10-CDKN2A Fusion FISH Probe
The MYH10-CDKN2A Fusion FISH Probe is used to confirm a fusion of the MYH10 and CDKN2A genes. The fusion of the MYH10 and CDKN2A genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYH10-CDKN2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-RERE | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-REOR | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-REGO | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-REGR | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-REAQ | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-ORRE | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-OROR | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-ORGO | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-GORE | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-GOOR | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-GOGO | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-GOGR | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-GRRE | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-GROR | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-GRGO | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-GRGR | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-AQRE | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-AQOR | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-AQGO | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-AQGR | 20 (40 μL) | 200 μL |
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| MYH10-CDKN2A-20-AQAQ | 20 (40 μL) | 200 μL |
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CDKN2A Gene Summary
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
Gene Name: Cyclin Dependent Kinase Inhibitor 2A
Chromosome: CHR9: 21967750 -21994490
Locus: 9p21.3
MYH10 Gene Summary
This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Myosin Heavy Chain 10
Chromosome: CHR17: 8377529 -8534036
Locus: 17p13.1
Gene Diseases
The MYH10 CDKN2A Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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