MYCBP2-TAF6L Fusion FISH Probe
The MYCBP2-TAF6L Fusion FISH Probe is used to confirm a fusion of the MYCBP2 and TAF6L genes. The fusion of the MYCBP2 and TAF6L genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYCBP2-TAF6L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-RERE | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-REOR | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-REGO | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-REGR | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-REAQ | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-ORRE | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-OROR | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-ORGO | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-GORE | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-GOOR | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-GOGO | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-GOGR | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-GRRE | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-GROR | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-GRGO | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-GRGR | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-AQRE | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-AQOR | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-AQGO | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-AQGR | 20 (40 μL) | 200 μL |
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| MYCBP2-TAF6L-20-AQAQ | 20 (40 μL) | 200 μL |
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TAF6L Gene Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]
Gene Name: TATA-box Binding Protein Associated Factor 6 Like
Chromosome: CHR11: 62538774 -62554813
Locus: 11q12.3
MYCBP2 Gene Summary
This gene encodes an E3 ubiquitin-protein ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect. [provided by RefSeq, Mar 2017]
Gene Name: MYC Binding Protein 2, E3 Ubiquitin Protein Ligase
Chromosome: CHR13: 77618791 -77901177
Locus: 13q22.3
Gene Diseases
The MYCBP2 TAF6L Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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