MYCBP2-CPB2 Fusion FISH Probe
The MYCBP2-CPB2 Fusion FISH Probe is used to confirm a fusion of the MYCBP2 and CPB2 genes. The fusion of the MYCBP2 and CPB2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYCBP2-CPB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-RERE | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-REOR | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-REGO | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-REGR | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-REAQ | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-ORRE | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-OROR | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-ORGO | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-GORE | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-GOOR | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-GOGO | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-GOGR | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-GRRE | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-GROR | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-GRGO | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-GRGR | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-AQRE | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-AQOR | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-AQGO | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-AQGR | 20 (40 μL) | 200 μL |
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| MYCBP2-CPB2-20-AQAQ | 20 (40 μL) | 200 μL |
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CPB2 Gene Summary
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Gene Name: Carboxypeptidase B2
Chromosome: CHR13: 46627321 -46679211
Locus: 13q14.13
MYCBP2 Gene Summary
This gene encodes an E3 ubiquitin-protein ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect. [provided by RefSeq, Mar 2017]
Gene Name: MYC Binding Protein 2, E3 Ubiquitin Protein Ligase
Chromosome: CHR13: 77618791 -77901177
Locus: 13q22.3
Gene Diseases
The MYCBP2 CPB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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