MYBPC1-PXN Fusion FISH Probe
The MYBPC1-PXN Fusion FISH Probe is used to confirm a fusion of the MYBPC1 and PXN genes. The fusion of the MYBPC1 and PXN genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MYBPC1-PXN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-RERE | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-REOR | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-REGO | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-REGR | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-REAQ | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-ORRE | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-OROR | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-ORGO | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-ORAQ | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-GORE | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-GOOR | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-GOGO | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-GOGR | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-GOAQ | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-GRRE | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-GROR | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-GRGO | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-GRGR | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-GRAQ | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-AQRE | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-AQOR | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-AQGO | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-AQGR | 20 (40 μL) | 200 μL |
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| MYBPC1-PXN-20-AQAQ | 20 (40 μL) | 200 μL |
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MYBPC1 Gene Summary
This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Gene Name: Myosin Binding Protein C, Slow Type
Chromosome: CHR12: 101988746 -102079658
Locus: 12q23.2
PXN Gene Summary
This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
Gene Name: Paxillin
Chromosome: CHR12: 120648241 -120703574
Locus: 12q24.23
Gene Diseases
The MYBPC1 PXN Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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