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MYB-NFIB Fusion FISH Probe

The MYB-NFIB Fusion FISH Probe is used to confirm a fusion of the MYB and NFIB genes. The fusion of the MYB and NFIB genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
MYB-NFIB-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
MYB-NFIB-20-RERE 20 (40 μL) 200 μL
MYB-NFIB-20-REOR 20 (40 μL) 200 μL
MYB-NFIB-20-REGO 20 (40 μL) 200 μL
MYB-NFIB-20-REGR 20 (40 μL) 200 μL
MYB-NFIB-20-REAQ 20 (40 μL) 200 μL
MYB-NFIB-20-ORRE 20 (40 μL) 200 μL
MYB-NFIB-20-OROR 20 (40 μL) 200 μL
MYB-NFIB-20-ORGO 20 (40 μL) 200 μL
MYB-NFIB-20-ORAQ 20 (40 μL) 200 μL
MYB-NFIB-20-GORE 20 (40 μL) 200 μL
MYB-NFIB-20-GOOR 20 (40 μL) 200 μL
MYB-NFIB-20-GOGO 20 (40 μL) 200 μL
MYB-NFIB-20-GOGR 20 (40 μL) 200 μL
MYB-NFIB-20-GOAQ 20 (40 μL) 200 μL
MYB-NFIB-20-GRRE 20 (40 μL) 200 μL
MYB-NFIB-20-GROR 20 (40 μL) 200 μL
MYB-NFIB-20-GRGO 20 (40 μL) 200 μL
MYB-NFIB-20-GRGR 20 (40 μL) 200 μL
MYB-NFIB-20-GRAQ 20 (40 μL) 200 μL
MYB-NFIB-20-AQRE 20 (40 μL) 200 μL
MYB-NFIB-20-AQOR 20 (40 μL) 200 μL
MYB-NFIB-20-AQGO 20 (40 μL) 200 μL
MYB-NFIB-20-AQGR 20 (40 μL) 200 μL
MYB-NFIB-20-AQAQ 20 (40 μL) 200 μL

MYB Gene Summary

This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Gene Name: MYB Proto-oncogene, Transcription Factor

Chromosome: CHR6: 135502452 -135540311

Locus: 6q23.3

NFIB Gene Summary

The Nuclear Factor I B (NFIB) gene is located on chr9 :14081841-14398982 at 9p23-p22.3.

Gene Name: Nuclear Factor I B

Chromosome: CHR9: 14081841 -14398982

Locus: 9p23-p22.3

Gene Diseases

The MYB NFIB Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Genetic rearrangements, hotspot mutations, and microRNA expression in the progression of metastatic adenoid cystic carcinoma of the salivary gland

Adenoid cystic carcinoma (ACC) is a common salivary gland malignancy. The malignancy is associated with gene fusions between MYB, MYBL1, and NFIB. FISH analysis was used to evaluate any rearrangements in these genes with the use of our break apart probes. It was found through FISH that MYB aberrations were preserved between primary tumors and metastases. Additionally, MYB and NFIB aberrations are preserved in ACC metastatic lesions.
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Recurrent rearrangements of the PLAG1 and HMGA2 genes in lacrimal gland pleomorphic adenoma and carcinoma ex pleomorphic adenoma

Lacrimal gland tumors are histologically similar to salivary gland tumors. In the salivary glands, pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (ca_ex_PA) are both characterized by PLAG1 and HMGA2 gene rearrangements. However, it is not known if these rearrangements are present in lacrimal gland PA and ca_ex_PA. FISH analysis was done with our PLAG1, HMGA2, and NFIB break apart probes. It was found that rearrangements were frequent in the tested lacrimal glands and that testing for the rearrangement can help in distinguishing lacrimal gland PA and ca_ex_PA from de novo carcinomas.
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MicroRNA dysregulation in adenoid cystic carcinoma of the salivary gland in relation to prognosis and gene fusion status: a cohort study

Adenoid cystic carcinoma (ACC) is a frequent malignancy of the salivary gland that is challenging due to an unpredictable clinical course. In hopes of improving this predictability, the association of microRNA with prognostic value in ACC is under study. Along with microRNA tests, FISH analysis was performed with various break apart probes, including our MYLB1 and NFIB probes, to look for any fusion or rearrangement. It was found that several microRNAs were associated with the outcome of ACC and that the most unifying feature of ACC is still involvement of the MYB gene.
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Molecular features of adenoid cystic carcinoma with an emphasis on microRNA expression

Adenoid cystic carcinoma (ACC) is a subtype of salivary gland tumor that can have a poor prognosis. ACC can also be present in lacrimal glands and the breasts with the tumors appearing to be seemingly identical to one another. The phenotypes, genetics, and microRNA expression of ACC in the salivary glands, lacrimal glands, and breasts was characterized in order to better understand the differences between them. Among other characterization tools, FISH analysis was performed with several break apart probes, including our MYBL1 and NFIB probes. The results seemed to indicate that microRNA has value in distinguishing between the tumors.
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