MXI1-KLK3 Fusion FISH Probe
The MXI1-KLK3 Fusion FISH Probe is used to confirm a fusion of the MXI1 and KLK3 genes. The fusion of the MXI1 and KLK3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MXI1-KLK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-RERE | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-REOR | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-REGO | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-REGR | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-REAQ | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-ORRE | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-OROR | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-ORGO | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-GORE | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-GOOR | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-GOGO | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-GOGR | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-GRRE | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-GROR | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-GRGO | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-GRGR | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-AQRE | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-AQOR | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-AQGO | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-AQGR | 20 (40 μL) | 200 μL |
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| MXI1-KLK3-20-AQAQ | 20 (40 μL) | 200 μL |
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KLK3 Gene Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Kallikrein Related Peptidase 3
Chromosome: CHR19: 51358170 -51364020
Locus: 19q13.33
MXI1 Gene Summary
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]
Gene Name: MAX Interactor 1, Dimerization Protein
Chromosome: CHR10: 111967362 -112047123
Locus: 10q25.2
Gene Diseases
The MXI1 KLK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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