MXD1-ANTXR1 Fusion FISH Probe
The MXD1-ANTXR1 Fusion FISH Probe is used to confirm a fusion of the MXD1 and ANTXR1 genes. The fusion of the MXD1 and ANTXR1 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MXD1-ANTXR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-RERE | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-REOR | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-REGO | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-REGR | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-REAQ | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-ORRE | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-OROR | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-ORGO | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-GORE | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-GOOR | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-GOGO | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-GOGR | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-GRRE | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-GROR | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-GRGO | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-GRGR | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-AQRE | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-AQOR | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-AQGO | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-AQGR | 20 (40 μL) | 200 μL |
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| MXD1-ANTXR1-20-AQAQ | 20 (40 μL) | 200 μL |
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MXD1 Gene Summary
This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
Gene Name: MAX Dimerization Protein 1
Chromosome: CHR2: 70142172 -70170076
Locus: 2p13.3
ANTXR1 Gene Summary
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
Gene Name: Anthrax Toxin Receptor 1
Chromosome: CHR2: 69240275 -69476459
Locus: 2p13.3
Gene Diseases
The MXD1 ANTXR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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