MVP-KIF22 Fusion FISH Probe
The MVP-KIF22 Fusion FISH Probe is used to confirm a fusion of the MVP and KIF22 genes. The fusion of the MVP and KIF22 genes has been associated with Breast Invasive Carcinoma, and Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MVP-KIF22-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-RERE | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-REOR | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-REGO | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-REGR | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-REAQ | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-ORRE | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-OROR | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-ORGO | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-ORAQ | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-GORE | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-GOOR | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-GOGO | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-GOGR | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-GOAQ | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-GRRE | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-GROR | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-GRGO | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-GRGR | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-GRAQ | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-AQRE | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-AQOR | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-AQGO | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-AQGR | 20 (40 μL) | 200 μL |
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| MVP-KIF22-20-AQAQ | 20 (40 μL) | 200 μL |
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KIF22 Gene Summary
The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Name: Kinesin Family Member 22
Chromosome: CHR16: 29802057 -29816706
Locus: 16p11.2
MVP Gene Summary
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Gene Name: Major Vault Protein
Chromosome: CHR16: 29831714 -29859360
Locus: 16p11.2
Gene Diseases
The MVP KIF22 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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