MUC4-TNK2 Fusion FISH Probe
The MUC4-TNK2 Fusion FISH Probe is used to confirm a fusion of the MUC4 and TNK2 genes. The fusion of the MUC4 and TNK2 genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MUC4-TNK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-RERE | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-REOR | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-REGO | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-REGR | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-REAQ | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-ORRE | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-OROR | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-ORGO | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-GORE | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-GOOR | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-GOGO | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-GOGR | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-GRRE | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-GROR | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-GRGO | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-GRGR | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-AQRE | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-AQOR | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-AQGO | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-AQGR | 20 (40 μL) | 200 μL |
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| MUC4-TNK2-20-AQAQ | 20 (40 μL) | 200 μL |
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MUC4 Gene Summary
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008]
Gene Name: Mucin 4, Cell Surface Associated
Chromosome: CHR3: 195473637 -195538844
Locus: 3q29
TNK2 Gene Summary
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine Kinase Non Receptor 2
Chromosome: CHR3: 195590235 -195635880
Locus: 3q29
Gene Diseases
The MUC4 TNK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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