MUC2-CLCN3 Fusion FISH Probe
The MUC2-CLCN3 Fusion FISH Probe is used to confirm a fusion of the MUC2 and CLCN3 genes. The fusion of the MUC2 and CLCN3 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MUC2-CLCN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-RERE | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-REOR | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-REGO | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-REGR | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-REAQ | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-ORRE | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-OROR | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-ORGO | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-GORE | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-GOOR | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-GOGO | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-GOGR | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-GRRE | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-GROR | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-GRGO | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-GRGR | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-AQRE | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-AQOR | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-AQGO | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-AQGR | 20 (40 μL) | 200 μL |
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| MUC2-CLCN3-20-AQAQ | 20 (40 μL) | 200 μL |
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CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
MUC2 Gene Summary
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis. [provided by RefSeq, Oct 2016]
Gene Name: Mucin 2, Oligomeric Mucus/gel-forming
Chromosome: CHR11: 1074874 -1104417
Locus: 11p15.5
Gene Diseases
The MUC2 CLCN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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