MUC1-SIAE Fusion FISH Probe
The MUC1-SIAE Fusion FISH Probe is used to confirm a fusion of the MUC1 and SIAE genes. The fusion of the MUC1 and SIAE genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MUC1-SIAE-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-RERE | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-REOR | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-REGO | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-REGR | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-REAQ | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-ORRE | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-OROR | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-ORGO | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-ORAQ | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-GORE | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-GOOR | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-GOGO | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-GOGR | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-GOAQ | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-GRRE | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-GROR | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-GRGO | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-GRGR | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-GRAQ | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-AQRE | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-AQOR | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-AQGO | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-AQGR | 20 (40 μL) | 200 μL |
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| MUC1-SIAE-20-AQAQ | 20 (40 μL) | 200 μL |
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MUC1 Gene Summary
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Gene Name: Mucin 1, Cell Surface Associated
Chromosome: CHR1: 155158299 -155162706
Locus: 1q22
SIAE Gene Summary
This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Name: Sialic Acid Acetylesterase
Chromosome: CHR11: 124505684 -124546199
Locus: 11q24.2
Gene Diseases
The MUC1 SIAE Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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