MUC1-PKLR Fusion FISH Probe
The MUC1-PKLR Fusion FISH Probe is used to confirm a fusion of the MUC1 and PKLR genes. The fusion of the MUC1 and PKLR genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MUC1-PKLR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-RERE | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-REOR | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-REGO | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-REGR | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-REAQ | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-ORRE | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-OROR | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-ORGO | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-ORAQ | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-GORE | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-GOOR | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-GOGO | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-GOGR | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-GOAQ | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-GRRE | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-GROR | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-GRGO | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-GRGR | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-GRAQ | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-AQRE | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-AQOR | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-AQGO | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-AQGR | 20 (40 μL) | 200 μL |
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| MUC1-PKLR-20-AQAQ | 20 (40 μL) | 200 μL |
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MUC1 Gene Summary
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Gene Name: Mucin 1, Cell Surface Associated
Chromosome: CHR1: 155158299 -155162706
Locus: 1q22
PKLR Gene Summary
The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Pyruvate Kinase L/R
Chromosome: CHR1: 155259083 -155271225
Locus: 1q22
Gene Diseases
The MUC1 PKLR Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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