MUC1-FAM189B Fusion FISH Probe
The MUC1-FAM189B Fusion FISH Probe is used to confirm a fusion of the MUC1 and FAM189B genes. The fusion of the MUC1 and FAM189B genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MUC1-FAM189B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-RERE | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-REOR | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-REGO | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-REGR | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-REAQ | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-ORRE | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-OROR | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-ORGO | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-ORAQ | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-GORE | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-GOOR | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-GOGO | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-GOGR | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-GOAQ | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-GRRE | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-GROR | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-GRGO | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-GRGR | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-GRAQ | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-AQRE | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-AQOR | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-AQGO | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-AQGR | 20 (40 μL) | 200 μL |
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| MUC1-FAM189B-20-AQAQ | 20 (40 μL) | 200 μL |
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MUC1 Gene Summary
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Gene Name: Mucin 1, Cell Surface Associated
Chromosome: CHR1: 155158299 -155162706
Locus: 1q22
FAM189B Gene Summary
This gene is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW domain-containing protein which is involved in apoptosis and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Gene Name: Family With Sequence Similarity 189 Member B
Chromosome: CHR1: 155216995 -155225274
Locus: 1q22
Gene Diseases
The MUC1 FAM189B Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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