MTRR-FASTKD3 Fusion FISH Probe
The MTRR-FASTKD3 Fusion FISH Probe is used to confirm a fusion of the MTRR and FASTKD3 genes. The fusion of the MTRR and FASTKD3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MTRR-FASTKD3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-RERE | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-REOR | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-REGO | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-REGR | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-REAQ | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-ORRE | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-OROR | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-ORGO | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-ORAQ | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-GORE | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-GOOR | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-GOGO | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-GOGR | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-GOAQ | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-GRRE | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-GROR | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-GRGO | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-GRGR | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-GRAQ | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-AQRE | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-AQOR | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-AQGO | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-AQGR | 20 (40 μL) | 200 μL |
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| MTRR-FASTKD3-20-AQAQ | 20 (40 μL) | 200 μL |
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MTRR Gene Summary
This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: 5-methyltetrahydrofolate-homocysteine Methyltransferase Reductase
Chromosome: CHR5: 7869216 -7901235
Locus: 5p15.31
FASTKD3 Gene Summary
This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-binding RAP domain. The members of this family are ubiquitously expressed and are generally most abundant in mitochondria-enriched tissues such as heart, skeletal muscle and brown-adipose tissue. Some members of this protein family may play a role in apoptosis. The protein encoded by this gene interacts with components of the mitochondrial respiratory and translation networks. A pseudogene of this gene is also present on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Gene Name: FAST Kinase Domains 3
Chromosome: CHR5: 7859271 -7869150
Locus: 5p15.31
Gene Diseases
The MTRR FASTKD3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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