MTMR3-MB Fusion FISH Probe
The MTMR3-MB Fusion FISH Probe is used to confirm a fusion of the MTMR3 and MB genes. The fusion of the MTMR3 and MB genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MTMR3-MB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-RERE | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-REOR | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-REGO | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-REGR | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-REAQ | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-ORRE | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-OROR | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-ORGO | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-ORAQ | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-GORE | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-GOOR | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-GOGO | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-GOGR | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-GOAQ | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-GRRE | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-GROR | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-GRGO | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-GRGR | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-GRAQ | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-AQRE | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-AQOR | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-AQGO | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-AQGR | 20 (40 μL) | 200 μL |
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| MTMR3-MB-20-AQAQ | 20 (40 μL) | 200 μL |
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MB Gene Summary
This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Myoglobin
Chromosome: CHR22: 36002810 -36019401
Locus: 22q12.3
MTMR3 Gene Summary
This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Myotubularin Related Protein 3
Chromosome: CHR22: 30279157 -30426857
Locus: 22q12.2
Gene Diseases
The MTMR3 MB Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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