MTMR2-MAML2 Fusion FISH Probe
The MTMR2-MAML2 Fusion FISH Probe is used to confirm a fusion of the MTMR2 and MAML2 genes. The fusion of the MTMR2 and MAML2 genes has been associated with Breast Invasive Carcinoma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MTMR2-MAML2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-RERE | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-REOR | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-REGO | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-REGR | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-REAQ | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-ORRE | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-OROR | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-ORGO | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-ORAQ | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-GORE | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-GOOR | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-GOGO | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-GOGR | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-GOAQ | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-GRRE | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-GROR | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-GRGO | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-GRGR | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-GRAQ | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-AQRE | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-AQOR | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-AQGO | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-AQGR | 20 (40 μL) | 200 μL |
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| MTMR2-MAML2-20-AQAQ | 20 (40 μL) | 200 μL |
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MTMR2 Gene Summary
This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Name: Myotubularin Related Protein 2
Chromosome: CHR11: 95566043 -95657371
Locus: 11q21
MAML2 Gene Summary
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]
Gene Name: Mastermind Like Transcriptional Coactivator 2
Chromosome: CHR11: 95711439 -96076344
Locus: 11q21
Gene Diseases
The MTMR2 MAML2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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