MTIF2-PPP3R1 Fusion FISH Probe
The MTIF2-PPP3R1 Fusion FISH Probe is used to confirm a fusion of the MTIF2 and PPP3R1 genes. The fusion of the MTIF2 and PPP3R1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MTIF2-PPP3R1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-RERE | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-REOR | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-REGO | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-REGR | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-REAQ | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-ORRE | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-OROR | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-ORGO | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-ORAQ | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-GORE | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-GOOR | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-GOGO | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-GOGR | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-GOAQ | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-GRRE | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-GROR | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-GRGO | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-GRGR | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-GRAQ | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-AQRE | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-AQOR | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-AQGO | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-AQGR | 20 (40 μL) | 200 μL |
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| MTIF2-PPP3R1-20-AQAQ | 20 (40 μL) | 200 μL |
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MTIF2 Gene Summary
During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016]
Gene Name: Mitochondrial Translational Initiation Factor 2
Chromosome: CHR2: 55463755 -55496384
Locus: 2p16.1
PPP3R1 Gene Summary
The Protein Phosphatase 3 Regulatory Subunit B, Alpha (PPP3R1) gene is located on chr2 :68405988-68479651 at 2p14.
Gene Name: Protein Phosphatase 3 Regulatory Subunit B, Alpha
Chromosome: CHR2: 68405988 -68479651
Locus: 2p14
Gene Diseases
The MTIF2 PPP3R1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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