MTHFS-BCL2A1 Fusion FISH Probe
The MTHFS-BCL2A1 Fusion FISH Probe is used to confirm a fusion of the MTHFS and BCL2A1 genes. The fusion of the MTHFS and BCL2A1 genes has been associated with Kidney Renal Clear Cell Carcinoma, Liver Hepatocellular Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| MTHFS-BCL2A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| MTHFS-BCL2A1-20-AQAQ | 20 (40 μL) | 200 μL |
|
BCL2A1 Gene Summary
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: BCL2 Related Protein A1
Chromosome: CHR15: 80253231 -80263643
Locus: 15q25.1
MTHFS Gene Summary
The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Gene Name: Methenyltetrahydrofolate Synthetase
Chromosome: CHR15: 80135888 -80189627
Locus: 15q25.1
Gene Diseases
The MTHFS BCL2A1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Kidney Renal Clear Cell Carcinoma |
| Liver Hepatocellular Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|