MTAP-PTPRD Fusion FISH Probe
The MTAP-PTPRD Fusion FISH Probe is used to confirm a fusion of the MTAP and PTPRD genes. The fusion of the MTAP and PTPRD genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| MTAP-PTPRD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-RERE | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-REOR | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-REGO | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-REGR | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-REAQ | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-ORRE | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-OROR | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-ORGO | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-ORAQ | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-GORE | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-GOOR | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-GOGO | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-GOGR | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-GOAQ | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-GRRE | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-GROR | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-GRGO | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-GRGR | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-GRAQ | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-AQRE | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-AQOR | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-AQGO | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-AQGR | 20 (40 μL) | 200 μL |
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| MTAP-PTPRD-20-AQAQ | 20 (40 μL) | 200 μL |
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MTAP Gene Summary
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]
Gene Name: Methylthioadenosine Phosphorylase
Chromosome: CHR9: 21802634 -21865969
Locus: 9p21.3
PTPRD Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]
Gene Name: Protein Tyrosine Phosphatase, Receptor Type D
Chromosome: CHR9: 8314245 -10612723
Locus: 9p24.1-p23
Gene Diseases
The MTAP PTPRD Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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